Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 2/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.35 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.33 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.33 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL828394 | 0.85 | FFAR1 (0.40) | FFAR1SLC6A2SLC6A4SLC6A3PDE10A | |
| SCHEMBL826952 | 0.84 | FFAR1 (0.46) | FFAR1ARPDE10APIK3C3ALDH1A1 | |
| SCHEMBL826935 | 0.84 | FFAR1 (0.44) | FFAR1ARPDE10APIK3C3ALDH1A1 | |
| SCHEMBL828548 | 0.83 | FFAR1 (0.42) | FFAR1ARPDE10APIK3C3ALDH1A1 | |
| SCHEMBL827287 | 0.83 | FFAR1 (0.43) | FFAR1ARPDE10APIK3C3ALDH1A1 | |
| SCHEMBL827978 | 0.82 | FFAR1 (0.42) | FFAR1ARPDE10APIK3C3ALDH1A1 | |
| SCHEMBL828049 | 0.81 | FFAR1 (0.42) | FFAR1ARSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL828030 | 0.80 | FFAR1 (0.41) | FFAR1ARPDE10APPARGPIK3C3 | |
| SCHEMBL828026 | 0.80 | FFAR1 (0.43) | FFAR1ARPDE10APIK3C3ALDH1A1 | |
| SCHEMBL828396 | 0.80 | FFAR1 (0.41) | FFAR1ARPDE10APIK3C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143274-B2 | 1-(2H)-isoquinolone derivative | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2012-03-27 | — | — | US | disclosed |