Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APAF1 | O14727 | 1/20 | 0.40 |
| ▸ | CDC25B | P30305 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.40 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.40 |
| ▸ | AKT1 | P31749 | 11/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL828336 | 0.79 | TNKS (0.48) | APAF1CASP3SENP8SENP7ALDH1A1 | |
| SCHEMBL826935 | 0.78 | FFAR1 (0.44) | APAF1CASP3SENP8SENP7ALDH1A1 | |
| SCHEMBL2711139 | 0.78 | APAF1 (0.46) | APAF1CDC25BCASP3SENP8SENP7 | |
| SCHEMBL824947 | 0.78 | TDO2 (0.51) | APAF1CDC25BCASP3SENP8SENP7 | |
| SCHEMBL824701 | 0.77 | APAF1 (0.49) | APAF1CDC25BCASP3SENP8SENP7 | |
| SCHEMBL824716 | 0.77 | APAF1 (0.49) | APAF1CDC25BCASP3SENP8SENP7 | |
| SCHEMBL824737 | 0.76 | NR1I3 (0.49) | APAF1CDC25BCASP3SENP8SENP7 | |
| SCHEMBL827412 | 0.76 | FFAR1 (0.46) | APAF1CASP3SENP8SENP7ALDH1A1 | |
| SCHEMBL824950 | 0.75 | TDO2 (0.48) | APAF1CDC25BCASP3SENP8SENP7 | |
| SCHEMBL824945 | 0.74 | TDO2 (0.47) | APAF1CDC25BCASP3SENP8SENP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143274-B2 | 1-(2H)-isoquinolone derivative | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2012-03-27 | — | — | US | disclosed |