Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 2/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | F3 | P13726 | 1/20 | 0.56 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | NPC1 | O15118 | 3/20 | 0.54 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11290392 | 0.84 | MEN1 (0.54) | CYP2C9CYP1A2CYP3A4KMT2AMEN1 | |
| SCHEMBL11290388 | 0.84 | MEN1 (0.54) | CYP2C9CYP1A2CYP3A4KMT2AMEN1 | |
| SCHEMBL11816976 | 0.83 | MAPT (0.61) | CYP1A2F3KMT2AMEN1NPC1 | |
| SCHEMBL11816970 | 0.83 | MAPT (0.61) | CYP1A2F3KMT2AMEN1NPC1 | |
| SCHEMBL13044103 | 0.83 | MEN1 (0.50) | CYP2C9CYP1A2CYP3A4F3HSD11B1 | |
| SCHEMBL8346191 | 0.83 | CYP1A2 (0.62) | CYP1A2KMT2AMEN1NPC1NOD2 | |
| SCHEMBL8999995 | 0.83 | CYP1A2 (0.62) | CYP1A2KMT2AMEN1NPC1NOD2 | |
| SCHEMBL9448683 | 0.81 | MAPT (0.65) | CYP2C9CYP1A2CYP3A4F3HSD11B1 | |
| SCHEMBL9448690 | 0.81 | MAPT (0.65) | CYP2C9CYP1A2CYP3A4F3HSD11B1 | |
| SCHEMBL17818209 | 0.77 | MAPT (0.48) | CYP2C9CYP1A2CYP3A4HSD11B1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8304579-B2 | Boronic acid aryl analogs | JOHNS HOPKINS UNIVERSITY (US) | 2012-11-06 | — | — | US | disclosed |
| US-8304579-B2 | Boronic acid aryl analogs | JOHNS HOPKINS UNIVERSITY (US) | 2012-11-06 | — | — | US | disclosed |
| US-20110105431-A1 | Boronic Acid Aryl Analogs | JOHNS HOPKINS UNIVERSITY, JOHNS HOPKINS TECHNOLOGY TRANSFER | 2011-05-05 | — | — | US | disclosed |
| US-20110105431-A1 | Boronic Acid Aryl Analogs | JOHNS HOPKINS UNIVERSITY, JOHNS HOPKINS TECHNOLOGY TRANSFER | 2011-05-05 | — | — | US | disclosed |
| US-7829742-B2 | Boronic acid aryl analogs | JOHNS HOPKINS UNIVERSITY (US) | 2010-11-09 | — | — | US | disclosed |
| US-7829742-B2 | Boronic acid aryl analogs | JOHNS HOPKINS UNIVERSITY (US) | 2010-11-09 | — | — | US | disclosed |
| US-20080171723-A1 | Boronic Acid Aryl Analogs | John Hopkins University, Johns Hopkins Technology Transfer (US) | 2008-07-17 | — | — | US | disclosed |
| US-20080171723-A1 | Boronic Acid Aryl Analogs | John Hopkins University, Johns Hopkins Technology Transfer (US) | 2008-07-17 | — | — | US | disclosed |
| WO-2005063774-A1 | BORONIC ACID ARYL ANALOGS | JOHNS HOPKINS UNIVERSITY (US) | 2005-07-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110105431-A1 | Boronic Acid Aryl Analogs | BRCA1, BCOR, BCCIP | CYP2C9 1282/4885CYP1A2 768/4885CYP3A4 1176/4885 |
| US-20080171723-A1 | Boronic Acid Aryl Analogs | BRCA1, BCOR, BCCIP | CYP2C9 1282/4885CYP1A2 768/4885CYP3A4 1176/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.