Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 5/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.34 |
| ▸ | GAA | P10253 | 3/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ALDH1A2 | O94788 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5911507 | 0.93 | PLA2G4A (0.40) | PDE11AMAPTCSF1RGAAMAPK1 | |
| SCHEMBL8287111 | 0.91 | PDE11A (0.39) | PDE11AMAPTTP53RXFP1CSF1R | |
| SCHEMBL8285207 | 0.90 | PDE11A (0.38) | PDE11AMAPTTP53RXFP1ALDH1A1 | |
| SCHEMBL8287884 | 0.90 | TP53 (0.44) | MAPTTP53RXFP1ALDH1A1GAA | |
| SCHEMBL8287185 | 0.90 | PDE11A (0.38) | PDE11AMAPTTP53CSF1RALDH1A1 | |
| SCHEMBL8285208 | 0.89 | MAT2A (0.38) | PDE11AMAPTTP53RXFP1CSF1R | |
| SCHEMBL8285219 | 0.88 | PDE11A (0.39) | PDE11AALDH1A1GAAMAPK1HPGD | |
| SCHEMBL8287927 | 0.87 | NPC1 (0.41) | PDE11AMAPTALDH1A1GAAHPGD | |
| SCHEMBL8287150 | 0.86 | PDE11A (0.40) | PDE11AMAPTCSF1RALDH1A1GAA | |
| SCHEMBL8285235 | 0.86 | PDE11A (0.41) | PDE11AMAPTCSF1RALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |