Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | PRKCA | P17252 | 1/20 | 0.39 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.39 |
| ▸ | G6PD | P11413 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8285224 | 0.91 | PDE11A (0.41) | MAPTKDM4EGAASMN1; SMN2CYP2C9 | |
| SCHEMBL8285227 | 0.84 | PDE11A (0.40) | KDM4EGAACYP1A2CYP3A4CYP2C19 | |
| SCHEMBL8287380 | 0.82 | CYP1A2 (0.46) | MAPTSMN1; SMN2CYP1A2CYP3A4POLB | |
| SCHEMBL8285206 | 0.82 | PDE11A (0.43) | MAPTKDM4EGAASMN1; SMN2CYP1A2 | |
| SCHEMBL5871894 | 0.81 | PDE11A (0.43) | KDM4EGAASMN1; SMN2CYP1A2CYP3A4 | |
| SCHEMBL8362692 | 0.80 | CYP1A2 (0.40) | EGLN1MAPTKDM4EGAASMN1; SMN2 | |
| SCHEMBL8287451 | 0.80 | PDE11A (0.42) | KDM4EGAASMN1; SMN2CYP1A2CYP3A4 | |
| SCHEMBL8285237 | 0.79 | ALDH1A1 (0.41) | MAPTKDM4EGAASMN1; SMN2HPGD | |
| SCHEMBL8285194 | 0.79 | ALDH1A1 (0.43) | MAPTKDM4EGAASMN1; SMN2CYP1A2 | |
| SCHEMBL8361773 | 0.79 | PDE11A (0.44) | MAPTKDM4EGAASMN1; SMN2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |