SCHEMBL8285227

SCHEMBL8285227

Cc1nc2c(cc1-c1ccc(F)cc1)c(=O)cc(Nc1ccccc1)n2-c1ccccc1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PDE11A Q9HCR9 1/20 0.40
USP2 O75604 5/20 0.37
CYP1A2 P05177 5/20 0.37
MAT2A P31153 1/20 0.36
ALDH1A1 P00352 4/20 0.36
ALDH1A2 O94788 1/20 0.36
ALDH1A3 P47895 1/20 0.36
MEN1 O00255 4/20 0.35
KMT2A Q03164 4/20 0.35
CASP3 P42574 1/20 0.35
BLM P54132 1/20 0.35
NCOA1 Q15788 1/20 0.35
SENP8 Q96LD8 1/20 0.35
SENP7 Q9BQF6 1/20 0.35
SENP6 Q9GZR1 1/20 0.35
NCOA3 Q9Y6Q9 1/20 0.35
PTGS2 P35354 1/20 0.35
MAPK1 P28482 5/20 0.35
HSD17B10 Q99714 4/20 0.35
CYP2D6 P10635 3/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8285224 0.92 PDE11A (0.41) PDE11AALDH1A1MEN1KMT2AMAPK1
SCHEMBL8287380 0.88 CYP1A2 (0.46) USP2CYP1A2MAT2AALDH1A1MEN1
SCHEMBL5872009 0.85 PDE11A (0.44) PDE11AUSP2CYP1A2MAT2AALDH1A1
SCHEMBL8285191 0.84 EGLN1 (0.41) PDE11AUSP2CYP1A2ALDH1A1TSHR
SCHEMBL5871894 0.82 PDE11A (0.43) PDE11AUSP2CYP1A2MAT2AALDH1A1
SCHEMBL8287862 0.82 PDE11A (0.42) PDE11AUSP2CYP1A2MAT2AALDH1A1
SCHEMBL8287451 0.81 PDE11A (0.42) PDE11AUSP2CYP1A2MAT2AALDH1A1
SCHEMBL8285194 0.80 ALDH1A1 (0.43) PDE11AUSP2CYP1A2ALDH1A1MEN1
SCHEMBL8361773 0.80 PDE11A (0.44) PDE11AUSP2CYP1A2MAT2AALDH1A1
SCHEMBL5871540 0.80 PDE11A (0.42) PDE11AUSP2CYP1A2MAT2AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2005091857-A2 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS BAYER PHARMACEUTICALS CORPORATION (US) 2005-10-06 WO disclosed
WO-2003027112-A1 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS BAYER PHARMACEUTICALS CORPORATION (US) 2003-04-03 WO disclosed