Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.44 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 4/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 3/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8285169 | 0.93 | PDE11A (0.45) | MAPTPDE11AGAAHPGDSMN1; SMN2 | |
| SCHEMBL8285193 | 0.90 | PDE11A (0.44) | MAPTPDE11AGAASMN1; SMN2HTT | |
| SCHEMBL8287388 | 0.89 | MAPT (0.48) | MAPTPDE11AGAAHPGDSMN1; SMN2 | |
| SCHEMBL8287393 | 0.86 | PDE11A (0.46) | MAPTPDE11AHPGDSMN1; SMN2HTT | |
| SCHEMBL5872175 | 0.86 | PDE11A (0.47) | MAPTPDE11AGAAHPGDSMN1; SMN2 | |
| SCHEMBL8285220 | 0.85 | PDE11A (0.43) | MAPTPDE11ASMN1; SMN2MEN1KMT2A | |
| SCHEMBL5871541 | 0.85 | PDE11A (0.46) | MAPTPDE11AGAAHPGDSMN1; SMN2 | |
| SCHEMBL8287516 | 0.85 | RIPK1 (0.50) | MAPTPDE11AGAAHPGDSMN1; SMN2 | |
| SCHEMBL8287397 | 0.84 | PDE11A (0.46) | MAPTPDE11AGAAHPGDSMN1; SMN2 | |
| SCHEMBL8287116 | 0.84 | PDE11A (0.48) | MAPTPDE11AGAAHPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |