Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 2/20 | 0.39 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.38 |
| ▸ | CDK4 | P11802 | 2/20 | 0.37 |
| ▸ | CCND1 | P24385 | 2/20 | 0.37 |
| ▸ | CCND2 | P30279 | 1/20 | 0.35 |
| ▸ | CCND3 | P30281 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | RXRA | P19793 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.35 |
| ▸ | MAT2A | P31153 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8285237 | 0.89 | ALDH1A1 (0.41) | PDE11ACDK4CCND1CCND2CCND3 | |
| SCHEMBL8285200 | 0.86 | MAPK1 (0.44) | PDE11AALDH1A1MAPK1LMNATP53 | |
| SCHEMBL8287153 | 0.86 | MAPT (0.40) | PDE11AALDH1A1MAPK1RXRATP53 | |
| SCHEMBL8285210 | 0.84 | PDE11A (0.44) | PDE11AALDH1A1MAPK1TP53GAA | |
| SCHEMBL8285199 | 0.84 | CSF1R (0.47) | ALDH1A1TP53CYP1A2CYP2C19GAA | |
| SCHEMBL8287199 | 0.84 | PDCD1 (0.40) | PDE11AALDH1A1MAPK1USP2LMNA | |
| SCHEMBL5871894 | 0.82 | PDE11A (0.43) | PDE11ACDK4CCND1CCND2CCND3 | |
| SCHEMBL8287126 | 0.82 | HDAC1 (0.37) | PDE11ACDK4CCND1RXRATP53 | |
| SCHEMBL8285215 | 0.82 | CNR2 (0.44) | PDE11AMAPK1LMNATP53MAPT | |
| SCHEMBL8287170 | 0.81 | PDE11A (0.38) | PDE11ACDK4CCND1CCND2CCND3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |