Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | CSF1R | P07333 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.35 |
| ▸ | CDK4 | P11802 | 3/20 | 0.34 |
| ▸ | CCND1 | P24385 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | CCND2 | P30279 | 2/20 | 0.34 |
| ▸ | CCND3 | P30281 | 2/20 | 0.34 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8285237 | 0.85 | ALDH1A1 (0.41) | PDE11ACNR2MAPTCSF1RGAA | |
| SCHEMBL8285215 | 0.84 | CNR2 (0.44) | PDE11ACNR2MAPTTP53RXFP1 | |
| SCHEMBL8287407 | 0.83 | PDE11A (0.43) | PDE11ACNR2MAPTGAATP53 | |
| SCHEMBL8287212 | 0.83 | HSD11B1 (0.40) | PDE11ACNR2MAPTGAATP53 | |
| SCHEMBL8287153 | 0.82 | MAPT (0.40) | PDE11AMAPTCSF1RGAATP53 | |
| SCHEMBL8285200 | 0.82 | MAPK1 (0.44) | PDE11ACNR2MAPTTP53CNR1 | |
| SCHEMBL8285197 | 0.81 | CXCR2 (0.39) | PDE11ACNR2MAPTCSF1RGAA | |
| SCHEMBL8287435 | 0.81 | KDM4E (0.39) | PDE11ACNR2GAA | |
| SCHEMBL8285210 | 0.81 | PDE11A (0.44) | PDE11ACNR2MAPTCSF1RGAA | |
| SCHEMBL8285199 | 0.80 | CSF1R (0.47) | MAPTCSF1RGAATP53HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |