Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | HPD | P32754 | 1/20 | 0.36 |
| ▸ | RXRA | P19793 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.35 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.35 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.35 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8285237 | 0.90 | ALDH1A1 (0.41) | MAPTALDH1A1PDE11AGAAGFER | |
| SCHEMBL8285200 | 0.87 | MAPK1 (0.44) | MAPTPOLBALDH1A1NPC1RAB9A | |
| SCHEMBL8285197 | 0.86 | CXCR2 (0.39) | MAPTALDH1A1PDE11AGAAGFER | |
| SCHEMBL8285210 | 0.85 | PDE11A (0.44) | MAPTALDH1A1PDE11AGAAGFER | |
| SCHEMBL5871894 | 0.85 | PDE11A (0.43) | ALDH1A1PDE11AGAAGFERHTT | |
| SCHEMBL8285215 | 0.85 | CNR2 (0.44) | MAPTNPC1RAB9APDE11ARXFP1 | |
| SCHEMBL8285199 | 0.85 | CSF1R (0.47) | MAPTPOLBALDH1A1NPC1RAB9A | |
| SCHEMBL8287199 | 0.85 | PDCD1 (0.40) | MAPTPOLBALDH1A1NPC1RAB9A | |
| SCHEMBL8287170 | 0.82 | PDE11A (0.38) | MAPTPOLBPDE11ARXFP1GAA | |
| SCHEMBL8287451 | 0.82 | PDE11A (0.42) | ALDH1A1NPC1RAB9APDE11AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |