Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 8/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 7/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 6/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CDK4 | P11802 | 1/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8285238 | 0.86 | PDE11A (0.49) | PDE11ARAB9AMEN1NPC1KMT2A | |
| SCHEMBL8285251 | 0.85 | PDE11A (0.48) | PDE11ARAB9AMEN1NPC1KMT2A | |
| SCHEMBL8287830 | 0.84 | PDE11A (0.48) | PDE11ARAB9AMEN1NPC1KMT2A | |
| SCHEMBL8286406 | 0.83 | PDE11A (0.44) | PDE11AKDM4EGAAALDH1A1MAPK1 | |
| SCHEMBL8286427 | 0.83 | RAB9A (0.51) | PDE11ARAB9ANPC1KDM4EALDH1A1 | |
| SCHEMBL8361760 | 0.82 | RAB9A (0.41) | RAB9AMEN1NPC1KMT2ANR2F2 | |
| SCHEMBL8287919 | 0.82 | ALDH1A1 (0.41) | PDE11ARAB9AMEN1NPC1KMT2A | |
| SCHEMBL8287435 | 0.81 | KDM4E (0.39) | PDE11ARAB9AKDM4EGAAALDH1A1 | |
| SCHEMBL8361763 | 0.81 | PDE11A (0.41) | PDE11AMEN1KMT2AKDM4EGAA | |
| SCHEMBL8285163 | 0.81 | POLB (0.50) | PDE11ARAB9AMEN1NPC1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |