Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 8/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.39 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.39 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 6/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | CRHBP | P24387 | 1/20 | 0.36 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8287451 | 0.85 | PDE11A (0.42) | KDM4ELMNASMN1; SMN2PDE11ARAB9A | |
| SCHEMBL8287564 | 0.84 | ALDH1A1 (0.38) | KDM4ELMNAPDE11ACNR2ALDH1A1 | |
| SCHEMBL8285198 | 0.81 | PDE11A (0.45) | KDM4ELMNASMN1; SMN2ADORA1ADORA2A | |
| SCHEMBL8287170 | 0.81 | PDE11A (0.38) | PDE11ACNR2GAA | |
| SCHEMBL5871894 | 0.80 | PDE11A (0.43) | KDM4ELMNASMN1; SMN2PDE11AALDH1A1 | |
| SCHEMBL8362865 | 0.80 | MAT2A (0.41) | KDM4ELMNASMN1; SMN2PDE11AADORA3 | |
| SCHEMBL8287426 | 0.79 | CYP3A4 (0.42) | KDM4ELMNASMN1; SMN2ADORA2APDE11A | |
| SCHEMBL8286404 | 0.79 | PDE11A (0.40) | KDM4ELMNASMN1; SMN2PDE11AALDH1A1 | |
| SCHEMBL8287487 | 0.78 | PDE11A (0.38) | KDM4EPDE11AALDH1A1GAA | |
| SCHEMBL8287277 | 0.78 | AOC3 (0.39) | KDM4ELMNAADORA1ADORA2APDE11A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |