Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NCF1 | P14598 | 2/20 | 0.47 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.42 |
| ▸ | KCNH3 | Q9ULD8 | 4/20 | 0.42 |
| ▸ | CFTR | P13569 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 4/20 | 0.38 |
| ▸ | HPGD | P15428 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | ATM | Q13315 | 2/20 | 0.38 |
| ▸ | GLA | P06280 | 2/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | CASP7 | P55210 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8285238 | 0.85 | PDE11A (0.49) | PDE11AKDM4EMAPK1GAAHPGD | |
| SCHEMBL8285244 | 0.84 | PDE11A (0.44) | PDE11AKDM4EMAPK1GAAHPGD | |
| SCHEMBL8287830 | 0.83 | PDE11A (0.48) | PDE11AKDM4EMAPK1GAAHPGD | |
| SCHEMBL8286379 | 0.83 | PDE11A (0.43) | PDE11AKDM4EMAPK1GAAHPGD | |
| SCHEMBL8286423 | 0.82 | KCNH3 (0.42) | NCF1PDE11AKCNH3CFTRKDM4E | |
| SCHEMBL8361761 | 0.82 | ALDH1A1 (0.42) | PDE11AKDM4EMAPK1HSD17B10GAA | |
| SCHEMBL8287405 | 0.82 | OPRK1 (0.53) | PDE11AKDM4EMAPK1GAAHPGD | |
| SCHEMBL8287832 | 0.80 | PDE11A (0.47) | PDE11AKDM4EMAPK1GAAHPGD | |
| SCHEMBL8361762 | 0.80 | OPRK1 (0.41) | PDE11AKDM4EMAPK1HSD17B10GAA | |
| SCHEMBL8286452 | 0.80 | PDE11A (0.44) | PDE11AKDM4EGAAHPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |