Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 3/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.38 |
| ▸ | CSF1R | P07333 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | PDE11A | Q9HCR9 | 2/20 | 0.36 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.35 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.35 |
| ▸ | GABRP | O00591 | 1/20 | 0.35 |
| ▸ | GABRD | O14764 | 1/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.35 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.35 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.35 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.35 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.35 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8287576 | 0.89 | GSK3B (0.39) | GSK3BMAPTPDE11ACDK4CCND1 | |
| SCHEMBL8285333 | 0.88 | GSK3B (0.36) | GSK3BPDE11ACDK4CCND1CCND2 | |
| SCHEMBL8287248 | 0.88 | MEN1 (0.43) | CSF1RMAPTKDM4EHSD17B10MAT2A | |
| SCHEMBL8287459 | 0.88 | GABRP (0.38) | GSK3BMAPTPDE11AGABRPGABRD | |
| SCHEMBL8287240 | 0.87 | HTT (0.41) | GSK3BCSF1RMAPTKDM4EPDE11A | |
| SCHEMBL8285329 | 0.87 | GSK3B (0.40) | GSK3BCSF1RKDM4EPDE11ACDK4 | |
| SCHEMBL8285335 | 0.86 | MAT2A (0.37) | GSK3BCSF1RPDE11ACDK4CCND1 | |
| SCHEMBL8285316 | 0.86 | PDE11A (0.40) | GSK3BMAPTPDE11ACDK4CCND1 | |
| SCHEMBL8287241 | 0.86 | RAB9A (0.40) | GSK3BCSF1RKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL8287482 | 0.86 | GSK3B (0.40) | GSK3BMAPTPDE11AGABRPGABRD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |