Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | GSK3B | P49841 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | GBA1 | P04062 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.33 |
| ▸ | RORC | P51449 | 2/20 | 0.33 |
| ▸ | KRAS | P01116 | 1/20 | 0.33 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.33 |
| ▸ | TNF | P01375 | 1/20 | 0.32 |
| ▸ | LITAF | Q99732 | 1/20 | 0.32 |
| ▸ | LCK | P06239 | 1/20 | 0.32 |
| ▸ | SRC | P12931 | 1/20 | 0.32 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8362922 | 0.91 | ALDH1A1 (0.42) | PDE11AJAK2BRD4ALDH1A1LMNA | |
| SCHEMBL8285282 | 0.89 | ALDH1A1 (0.42) | PDE11AALDH1A1GSK3BLMNAMEN1 | |
| SCHEMBL8287497 | 0.86 | PDE11A (0.46) | PDE11AALDH1A1GSK3BLMNALCK | |
| SCHEMBL8361778 | 0.86 | CDK4 (0.43) | PDE11AALDH1A1GSK3BLCKSRC | |
| SCHEMBL8287223 | 0.85 | PDE11A (0.39) | PDE11AJAK2BRD4ALDH1A1LMNA | |
| SCHEMBL8286467 | 0.84 | PDE11A (0.44) | PDE11AALDH1A1GSK3BLMNACDK4 | |
| SCHEMBL8287210 | 0.83 | PDE11A (0.43) | PDE11AALDH1A1GSK3BLMNATSHR | |
| SCHEMBL8287227 | 0.83 | PDE11A (0.37) | PDE11ANAMPTALDH1A1GSK3BLMNA | |
| SCHEMBL8287220 | 0.82 | CKS1B (0.41) | PDE11ACDK4CCND1CCND2CCND3 | |
| SCHEMBL8287946 | 0.82 | CDK4 (0.43) | PDE11AALDH1A1CDK4KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |