Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1D | P48730 | 3/20 | 0.74 |
| ▸ | GSK3A | P49840 | 3/20 | 0.74 |
| ▸ | GSK3B | P49841 | 3/20 | 0.74 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.74 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.74 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.74 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.74 |
| ▸ | SLC9A1 | P19634 | 14/20 | 0.63 |
| ▸ | RIPK1 | Q13546 | 3/20 | 0.58 |
| ▸ | PLK4 | O00444 | 2/20 | 0.56 |
| ▸ | AURKA | O14965 | 2/20 | 0.56 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.56 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.56 |
| ▸ | CDK1 | P06493 | 2/20 | 0.56 |
| ▸ | PIM1 | P11309 | 2/20 | 0.56 |
| ▸ | CDK2 | P24941 | 2/20 | 0.56 |
| ▸ | FLT4 | P35916 | 2/20 | 0.56 |
| ▸ | KDR | P35968 | 2/20 | 0.56 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.56 |
| ▸ | PLK1 | P53350 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL829114 | 0.91 | SLC9A1 (0.62) | CSNK1DGSK3AGSK3BDYRK1AAURKB | |
| SCHEMBL829128 | 0.88 | SLC9A1 (0.62) | CSNK1DGSK3AGSK3BDYRK1AAURKB | |
| SCHEMBL829766 | 0.87 | SLC9A1 (0.60) | CSNK1DGSK3AGSK3BDYRK1AAURKB | |
| SCHEMBL828534 | 0.86 | RPS6KB1 (0.57) | CSNK1DGSK3AGSK3BDYRK1AAURKB | |
| SCHEMBL828582 | 0.86 | SLC9A1 (0.65) | CSNK1DGSK3AGSK3BDYRK1AAURKB | |
| SCHEMBL829351 | 0.85 | SLC9A1 (0.69) | CSNK1DGSK3AGSK3BDYRK1AAURKB | |
| SCHEMBL829517 | 0.85 | SLC9A1 (0.64) | CSNK1DGSK3AGSK3BDYRK1AAURKB | |
| SCHEMBL829188 | 0.84 | SLC9A1 (0.65) | CSNK1DGSK3AGSK3BDYRK1AAURKB | |
| SCHEMBL830040 | 0.84 | SLC9A1 (0.64) | CSNK1DGSK3AGSK3BDYRK1AAURKB | |
| SCHEMBL829309 | 0.83 | SLC9A1 (0.66) | CSNK1DGSK3AGSK3BDYRK1AAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143307-B2 | Benzothiophen-2-carbonylguanidine derivatives, preparation thereof, and pharmaceutical composition containing the same | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2012-03-27 | — | — | US | disclosed |
| CN-101137641-B | Benzothiophen-2-carbonylguanidine derivatives, preparation thereof, and pharmaceutical composition containing the same | KOREA RES INST CHEM TECH | 2010-11-24 | — | — | CN | disclosed |
| US-20100004466-A1 | Benzothiophen-2-carbonylguanidine derivatives, preparation thereof, and pharmaceutical composition containing the same | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2010-01-07 | — | — | US | disclosed |
| EP-1831192-A4 | BENZOTHIOPHEN-2-CARBONYLGUANIDINE DERIVATIVES, PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME | KOREA RES INST CHEM TECH (KR) | 2009-08-19 | — | — | EP | disclosed |
| CN-101137641-A | Benzothiophen-2-carbonylguanidine derivatives, preparation thereof, and pharmaceutical composition containing the same | KOREA RES INST CHEM TECH (KR) | 2008-03-05 | — | — | CN | disclosed |
| EP-1831192-A1 | BENZOTHIOPHEN-2-CARBONYLGUANIDINE DERIVATIVES, PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME | Korea Research Institute of Chemical Technology (KR) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006071047-A1 | BENZOTHIOPHEN-2-CARBONYLGUANIDINE DERIVATIVES, PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2006-07-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100004466-A1 | Benzothiophen-2-carbonylguanidine derivatives, preparation thereof, and pharmaceutical composition containing the same | TNNI3, TNNT2, SLC9A2 | CSNK1D 1404/4885GSK3A 2056/4885GSK3B 1721/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.