Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 1.00 |
| ▸ | LMNA | P02545 | 7/20 | 1.00 |
| ▸ | NPSR1 | Q6W5P4 | 7/20 | 1.00 |
| ▸ | MEN1 | O00255 | 7/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 7/20 | 1.00 |
| ▸ | HPGD | P15428 | 6/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 1.00 |
| ▸ | HKDC1 | Q2TB90 | 4/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 1.00 |
| ▸ | HTT | P42858 | 4/20 | 1.00 |
| ▸ | CCR6 | P51684 | 3/20 | 1.00 |
| ▸ | ALOX12 | P18054 | 4/20 | 0.79 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.79 |
| ▸ | PKM | P14618 | 2/20 | 0.79 |
| ▸ | STAT3 | P40763 | 1/20 | 0.79 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.79 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.75 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.75 |
| ▸ | TNF | P01375 | 1/20 | 0.75 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9904910 | 0.89 | MAPT (0.87) | MAPTALDH1A1LMNANPSR1MEN1 | |
| SCHEMBL8285454 | 0.88 | MAPT (1.00) | MAPTALDH1A1LMNANPSR1MEN1 | |
| SCHEMBL8285456 | 0.86 | MAPT (1.00) | MAPTALDH1A1LMNANPSR1MEN1 | |
| SCHEMBL8285453 | 0.86 | MAPT (1.00) | MAPTALDH1A1LMNANPSR1MEN1 | |
| SCHEMBL10370782 | 0.81 | MAPT (0.67) | MAPTALDH1A1LMNANPSR1MEN1 | |
| SCHEMBL2489785 | 0.81 | MAPT (1.00) | MAPTALDH1A1LMNANPSR1MEN1 | |
| SCHEMBL12833654 | 0.79 | MAPT (0.65) | MAPTALDH1A1LMNANPSR1MEN1 | |
| SCHEMBL2555892 | 0.78 | MEN1 (0.81) | MAPTALDH1A1LMNANPSR1MEN1 | |
| SCHEMBL8286963 | 0.78 | MAPT (0.84) | MAPTALDH1A1LMNANPSR1MEN1 | |
| SCHEMBL9793702 | 0.73 | MAPT (0.61) | MAPTALDH1A1LMNANPSR1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005053609-A2 | METHODS OF NAD+-DEPENDENT DEACETYLASE INHIBITORS | GUILFORD PHARMACEUTICALS INC. (US) | 2005-06-16 | — | — | WO | disclosed |