Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 13/20 | 1.00 |
| ▸ | LMNA | P02545 | 11/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 1.00 |
| ▸ | HPGD | P15428 | 8/20 | 1.00 |
| ▸ | NPSR1 | Q6W5P4 | 8/20 | 1.00 |
| ▸ | MEN1 | O00255 | 7/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 7/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 1.00 |
| ▸ | HTT | P42858 | 5/20 | 1.00 |
| ▸ | ALOX12 | P18054 | 4/20 | 1.00 |
| ▸ | PKM | P14618 | 4/20 | 1.00 |
| ▸ | STAT3 | P40763 | 1/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 1/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.81 |
| ▸ | HKDC1 | Q2TB90 | 4/20 | 0.81 |
| ▸ | CCR6 | P51684 | 3/20 | 0.81 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.81 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.81 |
| ▸ | TNF | P01375 | 1/20 | 0.81 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9904910 | 0.93 | MAPT (0.87) | MAPTLMNAALDH1A1HPGDNPSR1 | |
| SCHEMBL8285456 | 0.89 | MAPT (1.00) | MAPTLMNAALDH1A1HPGDNPSR1 | |
| SCHEMBL8285453 | 0.89 | MAPT (1.00) | MAPTLMNAALDH1A1HPGDNPSR1 | |
| SCHEMBL8285451 | 0.88 | MAPT (1.00) | MAPTLMNAALDH1A1HPGDNPSR1 | |
| SCHEMBL8286963 | 0.81 | MAPT (0.84) | MAPTLMNAALDH1A1HPGDNPSR1 | |
| SCHEMBL9904567 | 0.79 | MAPT (0.78) | MAPTLMNAALDH1A1HPGDNPSR1 | |
| SCHEMBL10370782 | 0.78 | MAPT (0.67) | MAPTLMNAALDH1A1HPGDNPSR1 | |
| SCHEMBL9793702 | 0.76 | MAPT (0.61) | MAPTLMNAALDH1A1HPGDNPSR1 | |
| SCHEMBL17969801 | 0.76 | MAPT (0.61) | MAPTLMNAALDH1A1HPGDNPSR1 | |
| SCHEMBL12761935 | 0.76 | TBXAS1 (0.60) | MAPTLMNAALDH1A1HPGDNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110257146-A1 | Method of Treating Kcnq Related Disorders Using Organozinc Compounds | THE JOHNS HOPKINS UNIVERSITY (US) | 2011-10-20 | — | — | US | disclosed |
| US-20110257146-A1 | Method of Treating Kcnq Related Disorders Using Organozinc Compounds | THE JOHNS HOPKINS UNIVERSITY (US) | 2011-10-20 | — | — | US | disclosed |
| WO-2007087424-A2 | METHOD OF TREATING KCNQ RELATED DISORDERS USING ORGANOZINC COMPOUNDS | THE JOHNS HOPKINS UNIVERSITY (US) | 2007-08-02 | — | — | WO | disclosed |
| WO-2005053609-A2 | METHODS OF NAD+-DEPENDENT DEACETYLASE INHIBITORS | GUILFORD PHARMACEUTICALS INC. (US) | 2005-06-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110257146-A1 | Method of Treating Kcnq Related Disorders Using Organozinc Compounds | KCNQ3, KCNQ1, KCNQ5 | MAPT 3582/4885LMNA 2368/4885ALDH1A1 2097/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.