Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 8/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.40 |
| ▸ | HPGD | P15428 | 4/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | CDK4 | P11802 | 1/20 | 0.40 |
| ▸ | CCND1 | P24385 | 1/20 | 0.40 |
| ▸ | CCND2 | P30279 | 1/20 | 0.40 |
| ▸ | CCND3 | P30281 | 1/20 | 0.40 |
| ▸ | IGF1R | P08069 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8286110 | 0.94 | PDE11A (0.50) | PDE11AKDM4EHPGDTSHRHSD17B10 | |
| SCHEMBL8287829 | 0.93 | PDE11A (0.64) | PDE11AMAPTHPGDTSHRHSD17B10 | |
| SCHEMBL8287827 | 0.93 | PDE11A (0.51) | PDE11AMAPTKDM4EHPGDHSD17B10 | |
| SCHEMBL8287424 | 0.91 | PDE11A (0.48) | PDE11AMAPTKDM4ETSHRHSD17B10 | |
| SCHEMBL8287828 | 0.91 | PDE11A (0.49) | PDE11AKDM4EHPGDHSD17B10CDK4 | |
| SCHEMBL8286112 | 0.90 | NCF1 (0.50) | PDE11AMAPTKDM4EHPGDCDK4 | |
| SCHEMBL8286097 | 0.87 | PDE11A (0.45) | PDE11AGFERLMNAPOLB | |
| SCHEMBL8286111 | 0.87 | PDE11A (0.45) | PDE11AMAPTKDM4EHPGDTSHR | |
| SCHEMBL8287531 | 0.86 | PDE11A (0.44) | PDE11AMAPTMAPK1GAALMNA | |
| SCHEMBL8285163 | 0.83 | POLB (0.50) | PDE11AMAPTKDM4EHPGDTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |