Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.49 |
| ▸ | NCF1 | P14598 | 2/20 | 0.46 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.46 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CASP1 | P29466 | 2/20 | 0.40 |
| ▸ | CASP7 | P55210 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 2/20 | 0.39 |
| ▸ | KHK | P50053 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | CDK4 | P11802 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8286107 | 0.91 | PDE11A (0.54) | PDE11AALDH1A1HPGDHSD17B10POLB | |
| SCHEMBL8287827 | 0.90 | PDE11A (0.51) | PDE11ANCF1ALDH1A1HPGDCASP1 | |
| SCHEMBL8286110 | 0.89 | PDE11A (0.50) | PDE11AALDH1A1HPGDCYP1A2CASP1 | |
| SCHEMBL8287829 | 0.88 | PDE11A (0.64) | PDE11ANCF1HPGDUSP2CYP1A2 | |
| SCHEMBL8287424 | 0.86 | PDE11A (0.48) | PDE11AALDH1A1USP2CASP1CASP7 | |
| SCHEMBL8286112 | 0.85 | NCF1 (0.50) | PDE11ANCF1ALDH1A1HPGDPOLB | |
| SCHEMBL5871598 | 0.84 | PDE11A (0.58) | PDE11ANCF1ADRB1KDRALDH1A1 | |
| SCHEMBL8287531 | 0.84 | PDE11A (0.44) | PDE11ANCF1USP2CYP1A2CYP3A4 | |
| SCHEMBL8286097 | 0.82 | PDE11A (0.45) | PDE11ANCF1POLBHTR6 | |
| SCHEMBL8286111 | 0.82 | PDE11A (0.45) | PDE11AALDH1A1HPGDUSP2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |