Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.45 |
| ▸ | HTR7 | P34969 | 10/20 | 0.38 |
| ▸ | BRD1 | O95696 | 1/20 | 0.37 |
| ▸ | TAF1 | P21675 | 1/20 | 0.37 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.37 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 5/20 | 0.35 |
| ▸ | HTR2C | P28335 | 5/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.35 |
| ▸ | HTR1A | P08908 | 3/20 | 0.34 |
| ▸ | DRD2 | P14416 | 3/20 | 0.34 |
| ▸ | DRD3 | P35462 | 3/20 | 0.34 |
| ▸ | HTR6 | P50406 | 3/20 | 0.34 |
| ▸ | DRD4 | P21917 | 1/20 | 0.34 |
| ▸ | NCF1 | P14598 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.34 |
| ▸ | HTR1D | P28221 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8286110 | 0.87 | PDE11A (0.50) | PDE11ALMNAPOLB | |
| SCHEMBL8286107 | 0.87 | PDE11A (0.54) | PDE11ALMNAPOLBGFER | |
| SCHEMBL8287402 | 0.84 | PDE11A (0.39) | PDE11AHTR7BRD1TAF1BRPF1 | |
| SCHEMBL8287827 | 0.84 | PDE11A (0.51) | PDE11ANCF1LMNAPOLB | |
| SCHEMBL8287424 | 0.83 | PDE11A (0.48) | PDE11ALMNAPOLB | |
| SCHEMBL8287829 | 0.82 | PDE11A (0.64) | PDE11ANCF1LMNAPOLB | |
| SCHEMBL8287828 | 0.82 | PDE11A (0.49) | PDE11AHTR6NCF1POLB | |
| SCHEMBL8286112 | 0.82 | NCF1 (0.50) | PDE11ANCF1LMNAPOLBGFER | |
| SCHEMBL8286111 | 0.81 | PDE11A (0.45) | PDE11AP2RY12LMNAPOLB | |
| SCHEMBL8287531 | 0.80 | PDE11A (0.44) | PDE11AHTR7HTR2AHTR2CHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |