Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 7/20 | 0.46 |
| ▸ | MAPK9 | P45984 | 6/20 | 0.46 |
| ▸ | MAPK10 | P53779 | 6/20 | 0.46 |
| ▸ | MAT2A | P31153 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8286133 | 0.85 | MAT2A (0.50) | MAPK8MAPK9MAPK10MAT2AALDH1A1 | |
| SCHEMBL8286126 | 0.85 | MAPK8 (0.46) | MAPK8MAPK9MAPK10MAT2AALDH1A1 | |
| SCHEMBL8286135 | 0.83 | MAT2A (0.46) | MAPK8MAPK9MAPK10MAT2AALDH1A1 | |
| SCHEMBL8287392 | 0.81 | MAPK8 (0.47) | MAPK8MAPK9MAPK10MAT2AALDH1A1 | |
| SCHEMBL8286138 | 0.80 | MAT2A (0.43) | MAPK8MAPK9MAPK10MAT2AALDH1A1 | |
| SCHEMBL8285234 | 0.79 | MAT2A (0.47) | MAPK8MAPK9MAPK10MAT2AALDH1A1 | |
| SCHEMBL8285229 | 0.76 | MAPK8 (0.50) | MAPK8MAPK9MAPK10MAT2AALDH1A1 | |
| SCHEMBL8287156 | 0.76 | MAT2A (0.50) | MAPK8MAPK9MAPK10MAT2AALDH1A1 | |
| SCHEMBL8287183 | 0.74 | MAT2A (0.48) | MAPK8MAPK9MAPK10MAT2APOLB | |
| SCHEMBL5871674 | 0.73 | SMN1; SMN2 (0.50) | MAPK8MAPK9MAPK10MAT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |