Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 3/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.35 |
| ▸ | ALDH1A2 | O94788 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
| ▸ | CDK4 | P11802 | 1/20 | 0.34 |
| ▸ | CCND1 | P24385 | 1/20 | 0.34 |
| ▸ | CCND2 | P30279 | 1/20 | 0.34 |
| ▸ | CCND3 | P30281 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 3/20 | 0.34 |
| ▸ | RAB9A | P51151 | 3/20 | 0.34 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.34 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.34 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5871780 | 0.88 | PDE11A (0.41) | RIPK1CDK2CCNA2ALDH1A2ALDH1A1 | |
| SCHEMBL8287147 | 0.85 | HTT (0.44) | RIPK1ALDH1A1MAPTCSF1RSMN1; SMN2 | |
| SCHEMBL8287165 | 0.83 | HPGD (0.39) | ALDH1A1CSF1RMAPK10KDM4ECSNK2A1 | |
| SCHEMBL8287801 | 0.83 | ALDH1A2 (0.37) | ALDH1A2ALDH1A1ALDH1A3MAPTCDK4 | |
| SCHEMBL8287382 | 0.79 | PDE11A (0.43) | RIPK1ALDH1A2ALDH1A1ALDH1A3MAPT | |
| SCHEMBL8287383 | 0.77 | PDE11A (0.41) | RIPK1ALDH1A2ALDH1A1ALDH1A3CSF1R | |
| SCHEMBL8287859 | 0.77 | PDE11A (0.47) | LMNACDK2ALDH1A1KDM4EPIM1 | |
| SCHEMBL8287141 | 0.76 | PIK3CA (0.38) | ALDH1A2ALDH1A1ALDH1A3MAPTCDK4 | |
| SCHEMBL8286378 | 0.75 | PDE11A (0.49) | LMNARIPK1CDK2CCNA2MAPT | |
| SCHEMBL8287373 | 0.75 | PDE11A (0.40) | RIPK1ALDH1A2ALDH1A1ALDH1A3MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |