Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 4/20 | 0.36 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.35 |
| ▸ | STK10 | O94804 | 1/20 | 0.34 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | CD38 | P28907 | 1/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.33 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8285187 | 0.88 | PDE11A (0.62) | PDE11ALMNAMAPTSCN9AEPHB4 | |
| SCHEMBL8286374 | 0.86 | PDE11A (0.45) | PDE11AMAPTMDM2 | |
| SCHEMBL8287120 | 0.85 | PDE11A (0.49) | PDE11ASCN9AMDM2 | |
| SCHEMBL8287868 | 0.80 | PDE11A (0.47) | PDE11ALMNAMAPTTP53MDM2 | |
| SCHEMBL8285196 | 0.79 | PDE11A (0.64) | PDE11ALMNAMAPT | |
| SCHEMBL8286385 | 0.79 | PDE11A (0.79) | PDE11ATP53 | |
| SCHEMBL8361753 | 0.78 | PDE11A (0.46) | PDE11ALMNAMAPTTP53MDM2 | |
| SCHEMBL8286392 | 0.78 | PDE11A (0.62) | PDE11ALMNAMAPTTP53RIPK1 | |
| SCHEMBL8286089 | 0.77 | PDE11A (0.45) | PDE11ALMNAMAPTTP53MDM2 | |
| SCHEMBL8286388 | 0.77 | PDE11A (0.58) | PDE11ASCN9AMDM2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |