Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | BCHE | P06276 | 3/20 | 0.42 |
| ▸ | ACHE | P22303 | 3/20 | 0.42 |
| ▸ | ELANE | P08246 | 3/20 | 0.41 |
| ▸ | MGAM | O43451 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SI | P14410 | 1/20 | 0.41 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | PTGES | O14684 | 1/20 | 0.40 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.40 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | CSF1R | P07333 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | CDC25B | P30305 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | TYK2 | P29597 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5872077 | 0.89 | CSF1R (0.50) | HTTBCHEACHEELANEGAA | |
| SCHEMBL8287133 | 0.85 | ALDH1A1 (0.43) | BCHEACHEMAPTCSF1RSMN1; SMN2 | |
| SCHEMBL8286371 | 0.85 | LMNA (0.39) | MAPTCSF1RSMN1; SMN2ALDH1A1RIPK1 | |
| SCHEMBL8287801 | 0.79 | ALDH1A2 (0.37) | MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL8286374 | 0.78 | PDE11A (0.45) | HTTMAPK1BCHEACHEMGAM | |
| SCHEMBL8287373 | 0.76 | PDE11A (0.40) | HTTGAAMAPTCSF1RSMN1; SMN2 | |
| SCHEMBL8287383 | 0.75 | PDE11A (0.41) | MAPK1GAACSF1RSMN1; SMN2ALDH1A1 | |
| SCHEMBL8287382 | 0.74 | PDE11A (0.43) | MAPK1GAAMAPTCSF1RALDH1A1 | |
| SCHEMBL5871882 | 0.74 | CSF1R (0.48) | HTTBCHEACHEELANEGAA | |
| SCHEMBL8285199 | 0.74 | CSF1R (0.47) | HTTGAAMAPTNPSR1CSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |