Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.79 |
| ▸ | PIK3CB | P42338 | 9/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 8/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.42 |
| ▸ | AKT1 | P31749 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.40 |
| ▸ | BRAF | P15056 | 1/20 | 0.39 |
| ▸ | CTSL | P07711 | 1/20 | 0.39 |
| ▸ | CTSB | P07858 | 1/20 | 0.39 |
| ▸ | CTSS | P25774 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | SMG1 | Q96Q15 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8285154 | 0.88 | PDE11A (1.00) | PDE11APIK3CBPIK3CDPIK3CAAKT1 | |
| SCHEMBL8287391 | 0.86 | PDE11A (0.81) | PDE11APIK3CBPIK3CDPIK3CAAKT1 | |
| SCHEMBL8286388 | 0.86 | PDE11A (0.58) | PDE11APIK3CBPIK3CDPIK3CAKDM4E | |
| SCHEMBL8286364 | 0.82 | PDE11A (0.87) | PDE11APIK3CBPIK3CDPIK3CAKDM4E | |
| SCHEMBL5871369 | 0.79 | PDE11A (0.82) | PDE11APIK3CBPIK3CDPIK3CATP53 | |
| SCHEMBL8286378 | 0.79 | PDE11A (0.49) | PDE11ATP53 | |
| SCHEMBL8287524 | 0.78 | PDE11A (0.69) | PDE11APIK3CBPIK3CDPIK3CAAKT1 | |
| SCHEMBL8285151 | 0.78 | PDE11A (0.80) | PDE11ATP53 | |
| SCHEMBL8285158 | 0.78 | PDE11A (0.80) | PDE11AKDM4ETP53 | |
| SCHEMBL8287868 | 0.77 | PDE11A (0.47) | PDE11ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |