Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8287857 | 0.89 | PDE11A (0.56) | PDE11AHPGDCYP1A2CYP2C19CYP3A4 | |
| SCHEMBL8286094 | 0.86 | PDE11A (0.45) | PDE11AHPGDCYP1A2CYP2C19CYP3A4 | |
| SCHEMBL8361753 | 0.86 | PDE11A (0.46) | PDE11AHPGDCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL8287868 | 0.79 | PDE11A (0.47) | PDE11AMDM2LMNATP53MAPT | |
| SCHEMBL8286374 | 0.78 | PDE11A (0.45) | PDE11APOLBALDH1A1MDM2MAPT | |
| SCHEMBL8286378 | 0.77 | PDE11A (0.49) | PDE11AMDM2LMNATP53MAPT | |
| SCHEMBL8286369 | 0.77 | PDE11A (0.59) | PDE11AHPGDKDM4ETSHRTDP1 | |
| SCHEMBL8285140 | 0.75 | KCNH3 (0.44) | PDE11AHPGDKDM4EHSD17B10GLA | |
| SCHEMBL8287850 | 0.75 | PDE11A (0.56) | PDE11AADORA2AKCNH3LMNATP53 | |
| SCHEMBL8286385 | 0.75 | PDE11A (0.79) | PDE11AKDM4ETP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |