Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.58 |
| ▸ | PRKDC | P78527 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 5/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.34 |
| ▸ | CLK2 | P49760 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.32 |
| ▸ | SOS1 | Q07889 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | MTOR | P42345 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8286367 | 0.89 | PDE11A (0.73) | PDE11APRKDCPIK3CAPIK3CDPIK3CB | |
| SCHEMBL8286093 | 0.86 | PDE11A (0.59) | PDE11APRKDCPIK3CAPIK3CDPIK3CB | |
| SCHEMBL8286385 | 0.86 | PDE11A (0.79) | PDE11APIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL8287141 | 0.79 | PIK3CA (0.38) | PDE11APRKDCPIK3CAMEN1KMT2A | |
| SCHEMBL8287868 | 0.77 | PDE11A (0.47) | PDE11AMDM2 | |
| SCHEMBL8286378 | 0.77 | PDE11A (0.49) | PDE11ASCN9AMDM2NPC1RAB9A | |
| SCHEMBL8285153 | 0.76 | PDE11A (0.54) | PDE11APRKDCPIK3CAPIK3CDPIK3CB | |
| SCHEMBL8361753 | 0.75 | PDE11A (0.46) | PDE11ASYKMDM2MEN1KMT2A | |
| SCHEMBL8287579 | 0.75 | PDE11A (0.58) | PDE11ASYKHSD17B10NPC1RAB9A | |
| SCHEMBL8286059 | 0.75 | PDE11A (0.45) | PDE11APRKDCLRRK2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |