Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.44 |
| ▸ | MAT2A | P31153 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 13/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.38 |
| ▸ | PRKDC | P78527 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | CASP1 | P29466 | 2/20 | 0.37 |
| ▸ | CASP7 | P55210 | 2/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8285179 | 0.86 | PDE11A (0.58) | PDE11AMAT2ATSHRPIK3CBPIK3CA | |
| SCHEMBL8287873 | 0.83 | PIK3CB (0.36) | PIK3CBPIK3CAPIK3CDPIK3CG | |
| SCHEMBL5872167 | 0.79 | MAT2A (0.34) | MAT2AMEN1KMT2APIK3CDALDH1A1 | |
| SCHEMBL8287169 | 0.78 | PDE11A (0.47) | PDE11ATSHRMEN1KMT2AALDH1A1 | |
| SCHEMBL8287859 | 0.77 | PDE11A (0.47) | PDE11ATSHRPIK3CBPIK3CAPIK3CD | |
| SCHEMBL8287122 | 0.73 | PDE11A (0.44) | PDE11ATSHRMEN1KMT2APRKDC | |
| SCHEMBL8287855 | 0.71 | PDE11A (0.56) | PDE11AMAT2ATSHRMEN1KMT2A | |
| SCHEMBL8286052 | 0.70 | PDE11A (0.63) | PDE11AMAT2ATSHRMEN1KMT2A | |
| SCHEMBL8287907 | 0.69 | EGFR (0.41) | PDE11AMAT2ATSHRMEN1KMT2A | |
| SCHEMBL8287909 | 0.69 | MAPT (0.44) | MEN1KMT2AALDH1A1CYP1A2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |