Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 4/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8287909 | 0.87 | MAPT (0.44) | HPGDMEN1ALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL8285126 | 0.83 | PDE11A (0.36) | EGFRHPGDKDM4EMEN1ALDH1A1 | |
| SCHEMBL8287169 | 0.82 | PDE11A (0.47) | HPGDKDM4EMEN1ALDH1A1CYP1A2 | |
| SCHEMBL8285179 | 0.78 | PDE11A (0.58) | ADORA3ADORA2AHPGDKDM4EALDH1A1 | |
| SCHEMBL8287932 | 0.77 | KDM4E (0.40) | EGFRCNR1KDM4EALDH1A1MAPK1 | |
| SCHEMBL8287143 | 0.77 | BTK (0.39) | KDM4EMEN1ALDH1A1TSHRMAPK1 | |
| SCHEMBL8285115 | 0.76 | BPTF (0.36) | EGFRADORA3ADORA2AHPGDKDM4E | |
| SCHEMBL8287937 | 0.74 | DHODH (0.32) | KDM4EALDH1A1NPSR1SMN1; SMN2MAPT | |
| SCHEMBL8287122 | 0.73 | PDE11A (0.44) | ADORA2AHPGDKDM4EMEN1ALDH1A1 | |
| SCHEMBL8287906 | 0.73 | L3MBTL1 (0.39) | HPGDKDM4EMEN1ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |