Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | GALR2 | O43603 | 10/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8287907 | 0.87 | EGFR (0.41) | MAPTKMT2ASMN1; SMN2NPSR1MEN1 | |
| SCHEMBL8285132 | 0.82 | APP (0.40) | MAPTKMT2ALMNAHTTSMN1; SMN2 | |
| SCHEMBL8287169 | 0.80 | PDE11A (0.47) | MAPTKMT2ALMNAHTTSMN1; SMN2 | |
| SCHEMBL8287901 | 0.79 | MAPT (0.48) | MAPTKMT2ALMNAHTTSMN1; SMN2 | |
| SCHEMBL6796967 | 0.79 | TRPV4 (0.41) | MAPTKMT2ALMNAHTTSMN1; SMN2 | |
| SCHEMBL8287143 | 0.76 | BTK (0.39) | MAPTKMT2AHTTSMN1; SMN2MEN1 | |
| SCHEMBL8285179 | 0.76 | PDE11A (0.58) | MAPTLMNAHTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL8287932 | 0.75 | KDM4E (0.40) | LMNAHTTSMN1; SMN2ALDH1A1MAPK1 | |
| SCHEMBL5871610 | 0.73 | MEN1 (0.43) | MAPTKMT2ALMNAMEN1ALDH1A1 | |
| SCHEMBL8287906 | 0.72 | L3MBTL1 (0.39) | MAPTKMT2ALMNAHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |