Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.43 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.38 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 4/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5871824 | 0.85 | GAA (0.44) | L3MBTL1SMN1; SMN2KDM4ELMNAHTT | |
| SCHEMBL8286370 | 0.84 | L3MBTL1 (0.45) | L3MBTL1SMN1; SMN2TAAR1ABCC1ABCG2 | |
| SCHEMBL8287198 | 0.83 | L3MBTL1 (0.41) | L3MBTL1SMN1; SMN2TAAR1ABCC1ABCG2 | |
| SCHEMBL8285301 | 0.83 | L3MBTL1 (0.41) | L3MBTL1SMN1; SMN2TAAR1ABCC1ABCG2 | |
| SCHEMBL8286153 | 0.83 | ABCB1 (0.37) | POLB | |
| SCHEMBL8286449 | 0.78 | MAPT (0.40) | L3MBTL1SMN1; SMN2KDM4ELMNAHTT | |
| SCHEMBL8287801 | 0.74 | ALDH1A2 (0.37) | L3MBTL1SMN1; SMN2TAAR1ABCG2KDM4E | |
| SCHEMBL5872108 | 0.73 | GAA (0.44) | SMN1; SMN2KDM4ELMNAHTTGAA | |
| SCHEMBL8287944 | 0.72 | GAA (0.43) | SMN1; SMN2KDM4ELMNAHTTGAA | |
| SCHEMBL8286460 | 0.72 | PDE11A (0.43) | L3MBTL1SMN1; SMN2ABCG2KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |