Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE7A | Q13946 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 3/20 | 0.37 |
| ▸ | MAT2A | P31153 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | GAA | P10253 | 4/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CDK4 | P11802 | 1/20 | 0.34 |
| ▸ | CCND1 | P24385 | 1/20 | 0.34 |
| ▸ | CCND2 | P30279 | 1/20 | 0.34 |
| ▸ | CCND3 | P30281 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8285328 | 0.89 | GSK3B (0.38) | PDE7AGSK3BMAT2AALDH1A1GAA | |
| SCHEMBL8287515 | 0.88 | BCL6 (0.40) | PDE7AGSK3BMAT2AALDH1A1HPGD | |
| SCHEMBL8286498 | 0.87 | GAA (0.47) | GSK3BALDH1A1GAAHPGDLMNA | |
| SCHEMBL8285265 | 0.85 | ALDH1A1 (0.46) | ALDH1A1HPGDLMNASMN1; SMN2NPC1 | |
| SCHEMBL8287236 | 0.85 | MAT2A (0.40) | MAT2AALDH1A1GAALMNAMAPK1 | |
| SCHEMBL8287949 | 0.85 | GSK3B (0.40) | GSK3BMAT2AALDH1A1GAAHPGD | |
| SCHEMBL8287235 | 0.85 | NPC1 (0.49) | ALDH1A1LMNAHTTSMN1; SMN2NPC1 | |
| SCHEMBL8286150 | 0.83 | GSK3B (0.39) | GSK3BMAT2AALDH1A1GAAHPGD | |
| SCHEMBL8287512 | 0.82 | MAT2A (0.38) | GSK3BMAT2AALDH1A1GAAHPGD | |
| SCHEMBL5872050 | 0.82 | GAA (0.44) | GSK3BMAT2AALDH1A1GAAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |