Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAT2A | P31153 | 3/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8286498 | 0.89 | GAA (0.47) | ALDH1A1LMNAKDM4ENPC1GAA | |
| SCHEMBL8285265 | 0.87 | ALDH1A1 (0.46) | ALDH1A1LMNANPC1RAB9AL3MBTL1 | |
| SCHEMBL8287235 | 0.87 | NPC1 (0.49) | ALDH1A1LMNANPSR1KDM4ENPC1 | |
| SCHEMBL8286471 | 0.85 | PDE7A (0.38) | MAT2AALDH1A1LMNANPSR1NPC1 | |
| SCHEMBL8287247 | 0.83 | ALDH1A1 (0.46) | ALDH1A1LMNAGAARAB9AL3MBTL1 | |
| SCHEMBL8287923 | 0.83 | MAT2A (0.41) | MAT2AMAPK1TNK2EGFRMAPK8 | |
| SCHEMBL8285328 | 0.82 | GSK3B (0.38) | MAT2AALDH1A1LMNAKDM4ENPC1 | |
| SCHEMBL8287515 | 0.82 | BCL6 (0.40) | MAT2ARECQLALDH1A1LMNAKDM4E | |
| SCHEMBL8287481 | 0.82 | MAT2A (0.49) | MAT2AKDM4EGAAMAPK1TNK2 | |
| SCHEMBL8287949 | 0.79 | GSK3B (0.40) | MAT2AALDH1A1LMNANPC1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |