Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | KCNH3 | Q9ULD8 | 1/20 | 0.34 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.34 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.34 |
| ▸ | CDK4 | P11802 | 2/20 | 0.34 |
| ▸ | CCND1 | P24385 | 2/20 | 0.34 |
| ▸ | CCND2 | P30279 | 2/20 | 0.34 |
| ▸ | CCND3 | P30281 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | PDCD1 | Q15116 | 2/20 | 0.33 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.33 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8286100 | 0.84 | PDE11A (0.43) | PDE11AKDM4EALDH1A1MAPTHPGD | |
| SCHEMBL8287411 | 0.82 | PDE11A (0.41) | PDE11ACDK4CCND1CCND2CCND3 | |
| SCHEMBL5871965 | 0.80 | PDE11A (0.43) | PDE11AKDM4EALDH1A1HPGDMAPK8 | |
| SCHEMBL5872095 | 0.80 | PDE11A (0.43) | PDE11AALDH1A1MAPTHPGDCDK4 | |
| SCHEMBL8286099 | 0.80 | PDE11A (0.41) | PDE11AKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL8286191 | 0.77 | KCNH3 (0.37) | PDE11AKDM4EALDH1A1MAPTHPGD | |
| SCHEMBL5872390 | 0.77 | PDE11A (0.45) | PDE11AKDM4EALDH1A1HPGDMAPK8 | |
| SCHEMBL8287353 | 0.77 | CYP19A1 (0.47) | PDE11AMAPTCYP1A2CYP3A4 | |
| SCHEMBL5872134 | 0.76 | PDE11A (0.42) | PDE11AKDM4EALDH1A1CDK4LMNA | |
| SCHEMBL8285202 | 0.74 | NCF1 (0.47) | PDE11AKDM4EALDH1A1MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |