Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | IGF1R | P08069 | 1/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8287419 | 0.86 | PDE11A (0.51) | PDE11AKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL8285244 | 0.86 | PDE11A (0.44) | PDE11AKDM4EALDH1A1HTTMEN1 | |
| SCHEMBL8286558 | 0.85 | PDE11A (0.46) | PDE11AKDM4EALDH1A1HTTPTGS2 | |
| SCHEMBL8287532 | 0.84 | PDE11A (0.51) | PDE11AKDM4EALDH1A1KMT2APKM | |
| SCHEMBL8287405 | 0.83 | OPRK1 (0.53) | PDE11AKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL8361761 | 0.81 | ALDH1A1 (0.42) | PDE11AKDM4EALDH1A1HTTMEN1 | |
| SCHEMBL8361762 | 0.81 | OPRK1 (0.41) | PDE11AKDM4EALDH1A1HTTMEN1 | |
| SCHEMBL8361763 | 0.81 | PDE11A (0.41) | PDE11AKDM4EALDH1A1HTTMEN1 | |
| SCHEMBL8287842 | 0.81 | PDE11A (0.67) | PDE11AKDM4EALDH1A1HTTPTGS2 | |
| SCHEMBL8285238 | 0.79 | PDE11A (0.49) | PDE11AKDM4EALDH1A1HTTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |