Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | IGF1R | P08069 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8358804 | 0.86 | MAT2A (0.41) | PDE11AALDH1A1KDM4EHTTSMN1; SMN2 | |
| SCHEMBL8287409 | 0.85 | PDE11A (0.51) | PDE11AALDH1A1KDM4EHTTPTGS2 | |
| SCHEMBL8285337 | 0.84 | HSP90AA1 (0.47) | PDE11AALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL8285340 | 0.84 | PDE11A (0.45) | PDE11AALDH1A1KDM4EPKMSMN1; SMN2 | |
| SCHEMBL8286535 | 0.83 | OPRK1 (0.45) | PDE11AALDH1A1SMN1; SMN2GAAMAPT | |
| SCHEMBL5871913 | 0.81 | ALDH1A1 (0.42) | ALDH1A1KDM4EHTTMEN1KMT2A | |
| SCHEMBL8287944 | 0.79 | GAA (0.43) | PDE11AALDH1A1KDM4EHTTSMN1; SMN2 | |
| SCHEMBL8287403 | 0.79 | PDE11A (0.56) | PDE11AALDH1A1KDM4EHTTPKM | |
| SCHEMBL8287419 | 0.79 | PDE11A (0.51) | PDE11AALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL8287591 | 0.78 | LMNA (0.42) | PDE11AALDH1A1KDM4EHTTPTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |