Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.50 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8287393 | 0.92 | PDE11A (0.46) | RIPK1NR3C1MAPTALDH1A1LMNA | |
| SCHEMBL8287388 | 0.91 | MAPT (0.48) | RIPK1NR3C1MAPTALDH1A1GAA | |
| SCHEMBL8287394 | 0.87 | PDE11A (0.42) | RIPK1NR3C1MAPTALDH1A1GAA | |
| SCHEMBL5872175 | 0.86 | PDE11A (0.47) | MAPTALDH1A1GAALMNAHPGD | |
| SCHEMBL5871541 | 0.85 | PDE11A (0.46) | MAPTALDH1A1GAALMNAHPGD | |
| SCHEMBL8285205 | 0.85 | MAPT (0.44) | MAPTALDH1A1GAALMNAHPGD | |
| SCHEMBL8287397 | 0.84 | PDE11A (0.46) | MAPTALDH1A1GAALMNAHPGD | |
| SCHEMBL8286396 | 0.83 | PDE11A (0.44) | ALDH1A1GAAHPGDHTTPOLB | |
| SCHEMBL8286399 | 0.83 | PDE11A (0.46) | RIPK1MAPTGAAHPGDNPC1 | |
| SCHEMBL8285169 | 0.83 | PDE11A (0.45) | MAPTALDH1A1GAALMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |