Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.50 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.50 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.50 |
| ▸ | PREP | P48147 | 13/20 | 0.48 |
| ▸ | FAP | Q12884 | 4/20 | 0.48 |
| ▸ | DPP4 | P27487 | 2/20 | 0.48 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.48 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.48 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8287698 | 0.87 | PREP (0.47) | TAS1R3TAS1R1TAS1R2PREPFAP | |
| SCHEMBL12031801 | 0.85 | RAB9A (0.56) | PREPFAPDPP4DPP8DPP9 | |
| SCHEMBL12949782 | 0.85 | RAB9A (0.56) | PREPFAPDPP4DPP8DPP9 | |
| SCHEMBL12949796 | 0.84 | PREP (0.45) | PREPFAPDPP4DPP8DPP9 | |
| SCHEMBL16381899 | 0.82 | P2RX7 (0.46) | PREPFAPDPP4DPP8DPP9 | |
| SCHEMBL12031723 | 0.81 | RAB9A (0.51) | TAS1R3TAS1R1TAS1R2P2RX7 | |
| SCHEMBL13377307 | 0.80 | PREP (0.51) | PREPFAPDPP4DPP8DPP9 | |
| SCHEMBL12031885 | 0.78 | KMT2A (0.58) | PREPFAPDPP8DPP9HPGD | |
| SCHEMBL12949922 | 0.77 | PREP (0.54) | PREPFAPDPP4DPP8DPP9 | |
| SCHEMBL13377273 | 0.77 | PREP (0.43) | PREPFAPDPP4DPP8DPP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005085236-A2 | CASPASE INHIBITORS AND USES THEREOF | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2005-09-15 | — | — | WO | disclosed |