Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | GAA | P10253 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | MAT2A | P31153 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | ALPG | P10696 | 1/20 | 0.41 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.41 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.41 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5872091 | 0.90 | MAT2A (0.54) | LMNASMN1; SMN2GAAALDH1A1HPGD | |
| SCHEMBL8286340 | 0.89 | GAA (0.50) | LMNASMN1; SMN2GAAALDH1A1HPGD | |
| SCHEMBL8287894 | 0.89 | MAT2A (0.49) | LMNASMN1; SMN2GAAALDH1A1HPGD | |
| SCHEMBL8287872 | 0.87 | MAT2A (0.47) | LMNASMN1; SMN2ALDH1A1MAT2AMAPT | |
| SCHEMBL8287369 | 0.86 | MAT2A (0.52) | LMNASMN1; SMN2ALDH1A1HTTMAT2A | |
| SCHEMBL8286345 | 0.83 | MAT2A (0.50) | SMN1; SMN2ALDH1A1HPGDHTTMAT2A | |
| SCHEMBL8287837 | 0.81 | MAT2A (0.54) | LMNASMN1; SMN2ALDH1A1HTTMAT2A | |
| SCHEMBL8285127 | 0.80 | PDE11A (0.44) | LMNASMN1; SMN2GAAALDH1A1HPGD | |
| SCHEMBL8287867 | 0.79 | MAT2A (0.50) | ALDH1A1HTTMAT2AMAPTNPSR1 | |
| SCHEMBL8287881 | 0.78 | MAT2A (0.55) | LMNAGAAALDH1A1HPGDHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |