Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAT2A | P31153 | 5/20 | 0.50 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | C1R | P00736 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | APAF1 | O14727 | 1/20 | 0.39 |
| ▸ | TDP2 | O95551 | 1/20 | 0.39 |
| ▸ | CDC25B | P30305 | 1/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
| ▸ | CASP9 | P55211 | 1/20 | 0.39 |
| ▸ | CASP6 | P55212 | 1/20 | 0.39 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.39 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.39 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.39 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8287867 | 0.86 | MAT2A (0.50) | MAT2AADORA1C1RALDH1A1HTT | |
| SCHEMBL5872091 | 0.85 | MAT2A (0.54) | MAT2AADORA1HPGDALDH1A1HTT | |
| SCHEMBL8286340 | 0.85 | GAA (0.50) | MAT2AADORA1HPGDALDH1A1HTT | |
| SCHEMBL8287881 | 0.85 | MAT2A (0.55) | MAT2AADORA1HPGDALDH1A1HTT | |
| SCHEMBL8287899 | 0.83 | LMNA (0.49) | MAT2AADORA1HPGDALDH1A1HTT | |
| SCHEMBL8287894 | 0.81 | MAT2A (0.49) | MAT2AADORA1HPGDALDH1A1HTT | |
| SCHEMBL8287837 | 0.80 | MAT2A (0.54) | MAT2AADORA1ALDH1A1HTTCASP7 | |
| SCHEMBL8287872 | 0.79 | MAT2A (0.47) | MAT2AADORA1ALDH1A1L3MBTL1NPC1 | |
| SCHEMBL8287369 | 0.78 | MAT2A (0.52) | MAT2AALDH1A1HTTCASP7NPC1 | |
| SCHEMBL8285127 | 0.76 | PDE11A (0.44) | MAT2AADORA1HPGDALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |