Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 6/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 7/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | PDE9A | O76083 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | GBA1 | P04062 | 1/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | AKT1 | P31749 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8287898 | 0.87 | LMNA (0.38) | L3MBTL1MAPTALDH1A1KDM4EHTT | |
| SCHEMBL8287937 | 0.82 | DHODH (0.32) | L3MBTL1MAPTNPSR1ALDH1A1KDM4E | |
| SCHEMBL8285121 | 0.82 | ALDH1A1 (0.39) | L3MBTL1MAPTNPSR1ALDH1A1KDM4E | |
| SCHEMBL8287901 | 0.77 | MAPT (0.48) | POLBMAPTNPSR1ALDH1A1KDM4E | |
| SCHEMBL8287907 | 0.73 | EGFR (0.41) | MAPTNPSR1ALDH1A1KDM4EMAPK1 | |
| SCHEMBL8287909 | 0.72 | MAPT (0.44) | L3MBTL1POLBMAPTNPSR1ALDH1A1 | |
| SCHEMBL6801451 | 0.69 | LMNA (0.39) | L3MBTL1POLBMAPTNPSR1ALDH1A1 | |
| SCHEMBL8285179 | 0.69 | PDE11A (0.58) | MAPTALDH1A1ATMKDM4EHTT | |
| SCHEMBL8285122 | 0.68 | SMN1; SMN2 (0.36) | MAPTNPSR1ALDH1A1KDM4EMAPK1 | |
| SCHEMBL8286382 | 0.67 | PDE11A (0.44) | ALDH1A1ATMMAPK1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |