Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 4/20 | 0.54 |
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.54 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.46 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.46 |
| ▸ | HRH1 | P35367 | 2/20 | 0.41 |
| ▸ | GABBR2 | O75899 | 2/20 | 0.38 |
| ▸ | GABBR1 | Q9UBS5 | 2/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | AKT2 | P31751 | 1/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21022081 | 0.80 | GABBR2 (0.45) | GABBR2GABBR1 | |
| SCHEMBL13177593 | 0.80 | TAAR1 (0.43) | HTR2ATAAR1HRH1SLC6A2SLC6A4 | |
| SCHEMBL9441022 | 0.79 | DPP4 (0.38) | HTR2ATAAR1 | |
| SCHEMBL22199538 | 0.79 | SLC6A2 (0.35) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL13619947 | 0.74 | LMNA (0.40) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL149259 | 0.72 | HTR2A (1.00) | HTR2ATAAR1CHRNB2CHRNA4HRH1 | |
| SCHEMBL2313997 | 0.71 | MEN1 (0.38) | HTR2AHRH1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL20038755 | 0.71 | GABBR2 (0.43) | GABBR2GABBR1 | |
| SCHEMBL13700642 | 0.70 | KDM4E (0.43) | HTR2ASLC6A4 | |
| SCHEMBL13700569 | 0.70 | KDM4E (0.43) | HTR2ASLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005058298-A2 | FK228 ANALOGS AND THEIR USE AS HDAC-INHIBITORS | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2005-06-30 | — | — | WO | disclosed |