SCHEMBL828854

SCHEMBL828854

CCCOCC(COCCCCCC(=O)ON1C(=O)CCC1=O)OCCC

nearest known ligand 0.41

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
TLR2 O60603 8/20 0.41
LPAR1 Q92633 4/20 0.40
LPAR3 Q9UBY5 4/20 0.40
KMT2A Q03164 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
LPAR2 Q9HBW0 1/20 0.38
GAA P10253 1/20 0.36
ALDH1A1 P00352 1/20 0.35
LMNA P02545 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12628934 0.93 ALDH1A1 (0.45) LPAR1LPAR3SMN1; SMN2LPAR2ALDH1A1
SCHEMBL829055 0.89 ALDH1A1 (0.40) LPAR1LPAR3SMN1; SMN2LPAR2ALDH1A1
SCHEMBL12990161 0.87 SMN1; SMN2 (0.39) TLR2LPAR1LPAR3KMT2ASMN1; SMN2
SCHEMBL13563941 0.87 TLR2 (0.37) TLR2LPAR1LPAR3KMT2ASMN1; SMN2
SCHEMBL22667645 0.86 TLR2 (0.46) TLR2LPAR1LPAR3LPAR2
SCHEMBL15686246 0.85 TLR2 (0.34) TLR2LPAR1LPAR3LPAR2
SCHEMBL14985548 0.84 USP2 (0.37) KMT2ASMN1; SMN2ALDH1A1LMNA
SCHEMBL14401860 0.83 LPAR6 (0.37) LPAR1LPAR3SMN1; SMN2LPAR2ALDH1A1
SCHEMBL13369011 0.83 LPAR5 (0.37) LPAR1LPAR3KMT2ASMN1; SMN2LPAR2
SCHEMBL10196084 0.82 TLR2 (0.32) TLR2LPAR1LPAR3ALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20170240590-A1 NUCLEOPHILIC CATALYSTS FOR OXIME LINKAGE TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2017-08-24 US disclosed
US-9731024-B2 Nucleophilic catalysts for oxime linkage BAXALTA INCORPORATED (US) 2017-08-15 US disclosed
US-20160058842-A1 FACTOR VIII POLYMER CONJUGATES BAXTER INTERNATIONAL INC. 2016-03-03 US disclosed
US-20150024455-A1 NUCLEOPHILIC CATALYSTS FOR OXIME LINKAGE TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2015-01-22 US disclosed
US-8809501-B2 Nucleophilic catalysts for oxime linkage BAXTER INTERNATIONAL INC. (US) 2014-08-19 US disclosed
US-8637640-B2 Blood coagulation protein conjugates BAXTER INTERNATIONAL INC. (US) 2014-01-28 US disclosed
US-20130011900-A1 NUCLEOPHILIC CATALYSTS FOR OXIME LINKAGE BAXTER HEALTHCARE S.A. (CH) 2013-01-10 US disclosed
US-20120309021-A1 DETECTION OF ANTIBODY THAT BINDS TO WATER SOLUBLE POLYMER-MODIFIED POLYPEPTIDES BAXTER INTERNATIONAL INC. (US) 2012-12-06 US disclosed
US-20120232252-A1 FACTOR VIII POLYMER CONJUGATES BAXTER INTERNATIONAL INC. (US) 2012-09-13 US disclosed
US-8216793-B2 Detection of antibody that binds to water soluble polymer-modified polypeptides BAXTER INTERNATIONAL INC. (US) 2012-07-10 US disclosed
US-20100173830-A1 FACTOR VIII POLYMER CONJUGATES BAXTER HEALTHCARE S.A. (CH) 2010-07-08 US disclosed
US-20100173831-A1 FACTOR VIII POLYMER CONJUGATES BAXTER HEALTHCARE S.A. (CH) 2010-07-08 US disclosed
US-20100168391-A1 Pegylated Factor VIII BAXTER INTERNATIONAL INC. (US) 2010-07-01 US disclosed
US-20100113364-A1 FACTOR VIII POLYMER CONJUGATES BAXTER HEALTHCARE S.A. (CH) 2010-05-06 US disclosed
US-20100113365-A1 FACTOR VIII POLYMER CONJUGATES BAXTER HEALTHCARE S.A. (CH) 2010-05-06 US disclosed
US-20100093934-A1 PEGYLATION OF RECOMBINANT BLOOD COAGULATION FACTORS IN THE PRESENCE OF BOUND ANTIBODIES BAXTER INTERNATIONAL INC. (US) 2010-04-15 US disclosed
US-7683158-B2 Pegylated factor VIII BAXTER INTERNATIONAL INC. (US) 2010-03-23 US disclosed
US-7645860-B2 Factor VIII polymer conjugates BAXTER HEALTHCARE S.A. (CH) 2010-01-12 US disclosed
US-20090076237-A1 Factor VIII Polymer Conjugates BAXTER HEALTHCARE S.A. (CH) 2009-03-19 US disclosed
US-20070244301-A1 Pegylated factor VIII WELLS FARGO BANK, NATIONAL ASSOCIATION 2007-10-18 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (13 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170240590-A1 NUCLEOPHILIC CATALYSTS FOR OXIME LINKAGE LPO, OGA, DAO TLR2 2159/4885LPAR1 4103/4885LPAR3 4271/4885
US-20100093934-A1 PEGYLATION OF RECOMBINANT BLOOD COAGULATION FACTORS IN THE PRESENCE OF BOUND ANTIBODIES F8, F13B, F13A1 TLR2 3848/4885LPAR1 2583/4885LPAR3 3162/4885
US-20130011900-A1 NUCLEOPHILIC CATALYSTS FOR OXIME LINKAGE LPO, OGA, DAO TLR2 2159/4885LPAR1 4103/4885LPAR3 4271/4885
US-20100173830-A1 FACTOR VIII POLYMER CONJUGATES F8, F13B, F13A1 TLR2 3836/4885LPAR1 4216/4885LPAR3 4206/4885
US-20100173831-A1 FACTOR VIII POLYMER CONJUGATES F8, F13B, F13A1 TLR2 3836/4885LPAR1 4216/4885LPAR3 4206/4885
US-20090076237-A1 Factor VIII Polymer Conjugates F8, F13B, F13A1 TLR2 3836/4885LPAR1 4216/4885LPAR3 4206/4885
US-20100113365-A1 FACTOR VIII POLYMER CONJUGATES F8, F13B, F13A1 TLR2 3836/4885LPAR1 4216/4885LPAR3 4206/4885
US-20150024455-A1 NUCLEOPHILIC CATALYSTS FOR OXIME LINKAGE LPO, OGA, DAO TLR2 2159/4885LPAR1 4103/4885LPAR3 4271/4885
US-20070244301-A1 Pegylated factor VIII F8, F13B, F7 TLR2 3930/4885LPAR1 3416/4885LPAR3 3522/4885
US-20100168391-A1 Pegylated Factor VIII F8, F13B, F7 TLR2 3930/4885LPAR1 3416/4885LPAR3 3522/4885
US-20120232252-A1 FACTOR VIII POLYMER CONJUGATES F8, F13B, F13A1 TLR2 3836/4885LPAR1 4216/4885LPAR3 4206/4885
US-20100113364-A1 FACTOR VIII POLYMER CONJUGATES F8, F13B, F13A1 TLR2 3836/4885LPAR1 4216/4885LPAR3 4206/4885
US-20160058842-A1 FACTOR VIII POLYMER CONJUGATES F8, F13B, F13A1 TLR2 3836/4885LPAR1 4216/4885LPAR3 4206/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.