Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.72 |
| ▸ | RAB9A | P51151 | 2/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.72 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.72 |
| ▸ | TP53 | P04637 | 3/20 | 0.59 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.56 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | TNF | P01375 | 2/20 | 0.53 |
| ▸ | NOD1 | Q9Y239 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 6/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.52 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.52 |
| ▸ | RORC | P51449 | 1/20 | 0.52 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21247231 | 0.81 | MAPT (0.76) | NPC1RAB9AALDH1A1L3MBTL1TP53 | |
| SCHEMBL8288708 | 0.81 | TP53 (0.67) | NPC1RAB9AALDH1A1L3MBTL1TP53 | |
| SCHEMBL2182372 | 0.74 | TP53 (0.80) | NPC1RAB9AALDH1A1L3MBTL1TP53 | |
| SCHEMBL15281365 | 0.73 | CCR6 (0.56) | NPC1RAB9AALDH1A1L3MBTL1TP53 | |
| SCHEMBL21247383 | 0.69 | MAPT (0.73) | NPC1RAB9AALDH1A1L3MBTL1TP53 | |
| SCHEMBL21346818 | 0.69 | FLT3 (0.70) | NPC1RAB9AALDH1A1L3MBTL1TP53 | |
| SCHEMBL13744456 | 0.68 | NPC1 (0.74) | NPC1RAB9AL3MBTL1TP53MEN1 | |
| SCHEMBL23850645 | 0.68 | RORC (1.00) | NPC1RAB9AALDH1A1L3MBTL1TP53 | |
| SCHEMBL918283 | 0.68 | MAPT (1.00) | NPC1RAB9AALDH1A1L3MBTL1TP53 | |
| SCHEMBL8288764 | 0.68 | FLT3 (0.78) | NPC1RAB9AALDH1A1L3MBTL1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005033102-A2 | THIOPHENE-BASED COMPOUNDS EXHIBITING ATP-UTILIZING ENZYME INHIBITORY ACTIVITY, AND COMPOSITIONS, AND USES THEREOF | AMPHORA DISCOVERY CORPORATION (US) | 2005-04-14 | — | — | WO | disclosed |