Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.61 |
| ▸ | MEN1 | O00255 | 5/20 | 0.61 |
| ▸ | FLT3 | P36888 | 2/20 | 0.60 |
| ▸ | TNF | P01375 | 1/20 | 0.60 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.60 |
| ▸ | FABP4 | P15090 | 1/20 | 0.59 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 6/20 | 0.59 |
| ▸ | NPC1 | O15118 | 5/20 | 0.59 |
| ▸ | MAPT | P10636 | 4/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | CFTR | P13569 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.53 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13744456 | 0.86 | NPC1 (0.74) | TP53KMT2AMEN1FLT3TNF | |
| SCHEMBL8288764 | 0.85 | FLT3 (0.78) | TP53KMT2AMEN1FLT3TNF | |
| SCHEMBL15281390 | 0.81 | MAPK10 (0.77) | TP53KMT2AMEN1RAB9ANPC1 | |
| SCHEMBL8288554 | 0.81 | NPC1 (0.72) | TP53KMT2AMEN1TNFNOD1 | |
| SCHEMBL23493865 | 0.81 | TP53 (1.00) | TP53KMT2AMEN1FLT3TNF | |
| SCHEMBL21247391 | 0.79 | MEN1 (0.95) | TP53KMT2AMEN1FLT3TNF | |
| SCHEMBL20339108 | 0.78 | L3MBTL1 (0.67) | TP53KMT2AMEN1TNFNOD1 | |
| SCHEMBL8290453 | 0.77 | LMNA (0.64) | KMT2AMEN1MAPTLMNAALDH1A1 | |
| SCHEMBL21247135 | 0.76 | MEN1 (1.00) | TP53KMT2AMEN1FLT3TNF | |
| SCHEMBL23928917 | 0.75 | MEN1 (1.00) | TP53KMT2AMEN1TNFNOD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005033102-A2 | THIOPHENE-BASED COMPOUNDS EXHIBITING ATP-UTILIZING ENZYME INHIBITORY ACTIVITY, AND COMPOSITIONS, AND USES THEREOF | AMPHORA DISCOVERY CORPORATION (US) | 2005-04-14 | — | — | WO | disclosed |