Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 9/20 | 0.67 |
| ▸ | RAB9A | P51151 | 9/20 | 0.67 |
| ▸ | MEN1 | O00255 | 3/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.59 |
| ▸ | CASP3 | P42574 | 1/20 | 0.59 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.59 |
| ▸ | FLT3 | P36888 | 9/20 | 0.58 |
| ▸ | CFTR | P13569 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | XPO1 | O14980 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8290409 | 0.98 | NPC1 (0.70) | NPC1RAB9AMEN1KMT2ACASP3 | |
| SCHEMBL8289498 | 0.82 | FLT3 (0.79) | NPC1RAB9AMEN1KMT2ACASP3 | |
| SCHEMBL8288685 | 0.81 | FLT3 (0.77) | NPC1RAB9AMEN1KMT2ACASP3 | |
| SCHEMBL8289720 | 0.81 | NPC1 (0.73) | NPC1RAB9AMEN1KMT2AFLT3 | |
| SCHEMBL12218351 | 0.79 | NPC1 (0.98) | NPC1RAB9AMEN1KMT2ACASP3 | |
| SCHEMBL8290776 | 0.79 | NPC1 (1.00) | NPC1RAB9AMEN1KMT2ACASP3 | |
| SCHEMBL8290644 | 0.77 | NPC1 (0.96) | NPC1RAB9AMEN1KMT2AFLT3 | |
| SCHEMBL5453475 | 0.76 | ANO1 (0.65) | NPC1RAB9AMEN1KMT2ACASP3 | |
| SCHEMBL8290852 | 0.76 | FLT3 (0.75) | NPC1RAB9AMEN1KMT2ACASP3 | |
| SCHEMBL8290584 | 0.76 | FLT3 (0.95) | NPC1RAB9AMEN1KMT2ACASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005033102-A2 | THIOPHENE-BASED COMPOUNDS EXHIBITING ATP-UTILIZING ENZYME INHIBITORY ACTIVITY, AND COMPOSITIONS, AND USES THEREOF | AMPHORA DISCOVERY CORPORATION (US) | 2005-04-14 | — | — | WO | disclosed |