Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 2/20 | 0.58 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.58 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.49 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.49 |
| ▸ | CXCR2 | P25025 | 10/20 | 0.48 |
| ▸ | CXCR4 | P61073 | 4/20 | 0.48 |
| ▸ | KIF11 | P52732 | 1/20 | 0.45 |
| ▸ | FLT3 | P36888 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8288836 | 0.84 | PDE4B (0.57) | PDE4BPDE4DABCC1ABCG2CXCR2 | |
| SCHEMBL3913969 | 0.82 | FLT3 (0.64) | PDE4BPDE4DABCC1ABCG2CXCR2 | |
| SCHEMBL8289710 | 0.78 | KDM4E (0.70) | FLT3KDM4EMAPK1MEN1CYP1A2 | |
| SCHEMBL5459748 | 0.78 | FLT3 (0.70) | FLT3KDM4EMAPK1MEN1CYP1A2 | |
| SCHEMBL8289722 | 0.78 | PDE4B (0.52) | PDE4BPDE4DABCC1ABCG2CXCR2 | |
| SCHEMBL5462746 | 0.77 | MAPT (0.69) | PDE4BPDE4DKDM4E | |
| SCHEMBL8290436 | 0.77 | FLT3 (0.68) | FLT3KDM4EMAPK1MEN1CYP1A2 | |
| SCHEMBL5453397 | 0.75 | PTPN1 (0.53) | PDE4BPDE4DFLT3KDM4EMEN1 | |
| SCHEMBL8290782 | 0.74 | ALDH1A1 (0.53) | PDE4BPDE4DABCC1ABCG2CXCR2 | |
| SCHEMBL8290431 | 0.72 | ANO1 (0.72) | PDE4BPDE4DKDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005033102-A2 | THIOPHENE-BASED COMPOUNDS EXHIBITING ATP-UTILIZING ENZYME INHIBITORY ACTIVITY, AND COMPOSITIONS, AND USES THEREOF | AMPHORA DISCOVERY CORPORATION (US) | 2005-04-14 | — | — | WO | disclosed |