Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 5/20 | 0.62 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.62 |
| ▸ | HPGDS | O60760 | 1/20 | 0.59 |
| ▸ | KDR | P35968 | 1/20 | 0.59 |
| ▸ | NPC1 | O15118 | 9/20 | 0.58 |
| ▸ | RAB9A | P51151 | 9/20 | 0.58 |
| ▸ | MEN1 | O00255 | 5/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.58 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.56 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 4/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 4/20 | 0.56 |
| ▸ | NFKB2 | Q00653 | 4/20 | 0.56 |
| ▸ | RELA | Q04206 | 4/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | LCK | P06239 | 2/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27093077 | 0.90 | DYRK1A (0.67) | DYRK1ADYRK1BKDRNPC1RAB9A | |
| SCHEMBL4917177 | 0.87 | HPGDS (0.59) | DYRK1ADYRK1BHPGDSNPC1RAB9A | |
| SCHEMBL4124786 | 0.87 | DYRK1A (0.74) | DYRK1ADYRK1BKDRNPC1RAB9A | |
| SCHEMBL27093078 | 0.86 | KDR (0.75) | DYRK1ADYRK1BKDRNPC1RAB9A | |
| SCHEMBL4909989 | 0.85 | RAB9A (0.78) | DYRK1ADYRK1BHPGDSNPC1RAB9A | |
| SCHEMBL21568324 | 0.83 | DYRK1A (0.58) | DYRK1ADYRK1BKDRNPC1RAB9A | |
| SCHEMBL13329187 | 0.82 | HPGDS (0.69) | DYRK1AHPGDSNPC1RAB9AMEN1 | |
| SCHEMBL12199338 | 0.82 | HPGDS (0.69) | DYRK1AHPGDSNPC1RAB9AMEN1 | |
| SCHEMBL17001367 | 0.82 | DYRK1A (0.74) | DYRK1ADYRK1BNPC1RAB9AMEN1 | |
| SCHEMBL26034943 | 0.81 | DYRK1A (0.54) | DYRK1ADYRK1BNPC1RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005037845-A1 | BENZOTHIAZOLE AND THIAZOLE[5,5-B] PYRIDINE COMPOSITIONS AND THEIR USE AS UBIQUITIN LIGASE INHIBITORS | RIGEL PHARMACEUTICALS, INC. (US) | 2005-04-28 | — | — | WO | disclosed |