Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 6/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.42 |
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.38 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.38 |
| ▸ | MITF | O75030 | 1/20 | 0.38 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8288295 | 0.71 | MEN1 (0.55) | MEN1KMT2AMAPTUSP2LMNA | |
| SCHEMBL3893517 | 0.69 | MEN1 (0.69) | MEN1KMT2AMAPTNPC1RAB9A | |
| SCHEMBL3893522 | 0.69 | MEN1 (0.69) | MEN1KMT2AMAPTNPC1RAB9A | |
| SCHEMBL8288292 | 0.68 | CRHBP (0.55) | MEN1KMT2AMAPTNPC1RAB9A | |
| SCHEMBL13766517 | 0.67 | MAPT (0.45) | MEN1KMT2AMAPTUSP2ALDH1A1 | |
| SCHEMBL8289154 | 0.66 | FFAR1 (0.56) | MEN1KMT2AMAPTUSP2LMNA | |
| SCHEMBL8289161 | 0.63 | MEN1 (0.56) | MEN1KMT2AMAPTRAB9AUSP2 | |
| SCHEMBL7704002 | 0.63 | HSD17B3 (0.55) | MEN1KMT2AMAPTNPC1RAB9A | |
| SCHEMBL8537491 | 0.63 | HSD17B3 (0.55) | MEN1KMT2AMAPTNPC1RAB9A | |
| SCHEMBL7704006 | 0.63 | HSD17B3 (0.55) | MEN1KMT2AMAPTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005041951-A2 | RHODANINE DERIVATIVES FOR USE AS ANTIVIRAL AGENTS | RIGEL PHARMACEUTICALS, INC. (US) | 2005-05-12 | — | — | WO | disclosed |